Paul Leff

Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A and 2C Receptors: Evidence for Agonist-Directed Trafficking of Receptor Stimulus

Kelly A. Berg, Saul Maayani, Joseph Goldfarb et al. · Molecular Pharmacology · 1998 · 512 citations

The two-state model of receptor activation

Paul Leff · Trends in Pharmacological Sciences · 1995 · 504 citations

Signal Transduction, G Protein-coupled Receptor, Functional Selectivity +5

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

Richard A. Bond, Paul Leff, T. David Johnson et al. · Nature · 1995 · 420 citations

Molecular Pharmacology, Cardiac Muscle, Molecular Physiology +11

Antagonists of the Platelet P<i>_2T</i> Receptor:  A Novel Approach to Antithrombotic Therapy

Anthony H. Ingall, John Dixon, Andrew Bailey et al. · Journal of Medicinal Chemistry · 1999 · 285 citations

Antithrombotic Therapy, Novel Approach, Pharmacotherapy +17

From ATP to AZD6140: The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

Brian Springthorpe, A. S. Bailey, Patrick Barton et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 233 citations · Full text

Thrombosis, Platelet Aggregation Inhibitors, Biochemistry +8