Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

Philippe Samama, Susanna Cotecchia, Tommaso Costa et al. · Journal of Biological Chemistry · 1993 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Differential signal transduction by five splice variants of the PACAP receptor

Christian Waeber, C. Pantaloni, F Holsboer et al. · Nature · 1993 · 1.2K citations

Life Sciences, Molecular Biology, Pharmacology +13

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

Jasmine Parma, Laurence Duprez, Jacqueline Van Sande et al. · Nature · 1993 · 923 citations

Medicine, Endocrinology, Genetics +12

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

Andrew Shenker, Louisa Laue, Shinji Kosugi et al. · Nature · 1993 · 756 citations · Full text

Medicine, Endocrinology, Genetics +14

Enhanced Myocardial Function in Transgenic Mice Overexpressing the β ₂ -Adrenergic Receptor

Carmelo A. Milano, Lee F. Allen, Howard A. Rockman et al. · Science · 1994 · 746 citations

Medicine, Cardiology, Molecular Biology +17