Concepedia

Therapeutic Modulation

Therapeutic Modulation is a targeted biochemical intervention strategy within allosteric modulation that selectively alters protein function through binding at a site distinct from the active site to achieve desired physiological outcomes in disease treatment.

969

Publications

51K

Citations

8.6K

Authors

1.8K

Institutions

Publications per year

2017–2026

589

Parents

Publications

969

Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

Loren D. Walensky, Andrew L. Kung, Iris Escher et al. · Science · 2004 · 1.3K citations · Full text

, , +17

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

Desmond Padhi, Graham Jang, Brian Stouch et al. · Journal of Bone and Mineral Research · 2010 · 783 citations

, , +17

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

Cesar A. Corzo, Matthew J. Cotter, Pingyan Cheng et al. · The Journal of Immunology · 2009 · 751 citations · Full text

, , +17

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

Meghan J. Seltzer, Bryson D. Bennett, Avadhut D. Joshi et al. · Cancer Research · 2010 · 530 citations · Full text

, , +17

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice

Jing Sun, Jing‐Xuan Xu, Yi Ling et al. · Translational Psychiatry · 2019 · 524 citations · Full text

, , +17

1–5 of 969

Authors

8.6K

  1. MT
    Miduo Tan

    Zhuzhou Central Hospital, China

    3 publications · 151 citations

    3

    h-index

  2. MJ
    Matthew J. A. Wood

    University of Oxford, United Kingdom

    3 publications · 146 citations

    3

    h-index

  3. YT
    Yu‐Tzu Tai

    Dana-Farber Cancer Institute, United States

    3 publications · 283 citations

    3

    h-index

  4. EW
    Ernst Wagner

    Ludwig-Maximilians-Universität München, Germany

    3 publications · 68 citations

    3

    h-index

  5. SH
    Seung Hyun Kim

    Hanyang University, South Korea

    3 publications · 97 citations

    3

    h-index

1–5 of 8.6K

Institutions

1.8K

  1. Harvard University

    Cambridge, United States

    24 h-index

    112 publications

    19.2K citations

  2. Sun Yat-sen University

    Guangzhou, China

    20 h-index

    202 publications

    8.7K citations

  3. Shanghai Jiao Tong University

    Shanghai, China

    17 h-index

    109 publications

    6K citations

  4. Guangzhou Medical University

    Guangzhou, China

    16 h-index

    107 publications

    3.9K citations

  5. Inserm

    Paris, France

    16 h-index

    88 publications

    3.9K citations

  6. Fudan University

    Shanghai, China

    15 h-index

    64 publications

    2.5K citations

  7. Dana-Farber Cancer Institute

    Boston, United States

    13 h-index

    77 publications

    17.2K citations

  8. Central South University

    Changsha, China

    13 h-index

    101 publications

    4.8K citations

1–8 of 1.8K

Venues

  1. Nature Communications

    23 publications · 1.3K citations

    20

    h-index

  2. PLoS ONE

    23 publications · 1K citations

    20

    h-index

  3. PubMed

    Repository · 35 publications · 1.1K citations

    20

    h-index

  4. Scientific Reports

    24 publications · 1.1K citations

    19

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 1.9K citations

    14

    h-index

1–5