Tommaso Costa

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

Philippe Samama, Susanna Cotecchia, Tommaso Costa et al. · Journal of Biological Chemistry · 1993 · 1.2K citations · Full text

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

Tommaso Costa, A. Herz · Proceedings of the National Academy of Sciences · 1989 · 529 citations · Full text

Gtpase Activity, Pharmacotherapy, Molecular Pharmacology +18

Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation.

Alexander Scheer, Francesca Fanelli, Tommaso Costa et al. · The EMBO Journal · 1996 · 391 citations · Full text

Molecular Pharmacology, Signal Transduction, Molecular Physiology +10

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Dean P. Staus, Ryan T. Strachan, Aashish Manglik et al. · Nature · 2016 · 327 citations · Full text

Signal Transduction, Molecular Physiology, Biochemistry +12

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand.

Tommaso Costa, Yukiko Ogino, Peter J. Munson et al. · Molecular Pharmacology · 1992 · 242 citations