Influenza virus polymerase confers independence of the cellular cap-binding factor eIF4E for viral mRNA translation

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Carson C. Thoreen, Seong A. Kang, Jae Won Chang et al. · Journal of Biological Chemistry · 2009 · 1.8K citations · Full text

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

Michael Wigler, Àngel Pellicer, Saul J. Silverstein et al. · Proceedings of the National Academy of Sciences · 1979 · 1.3K citations · Full text

Aprt+ Phenotype, Protein Expression, Mouse Cells +15

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Morris E. Feldman, Beth Apsel, Aino Uotila et al. · PLoS Biology · 2009 · 1.1K citations · Full text

Drug Target, Mrna Translation, Molecular Biology +24

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Alexandre Dias, Denis Bouvier, Thibaut Crépin et al. · Nature · 2009 · 734 citations

Virus Structure, Viral Replication, Natural Sciences +10

A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription

Stephen J. Plotch, Michèle Bouloy, Ismo Ulmanen et al. · Cell · 1981 · 705 citations

Viral Replication, Systems Biology, Natural Sciences +6