Concepedia

Cap-dependent Translation Initiation

Cap-Dependent Translation Initiation is a translation initiation mechanism in eukaryotes in which the ribosome selectively recognizes and binds to the 5' mRNA cap structure via the cap-binding complex eIF4F, thereby facilitating the recruitment of the small ribosomal subunit and the initiation of protein synthesis.

587

Publications

50.7K

Citations

2.4K

Authors

638

Institutions

Publications per year

2017–2026

84

Parents

Publications

587

5′ UTR m6A Promotes Cap-Independent Translation

Kate D. Meyer, Deepak P. Patil, Jun Zhou et al. · Cell · 2015 · 1.8K citations · Full text

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Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells

Ryan J.O. Dowling, Mahvash Zakikhani, I. George Fantus et al. · Cancer Research · 2007 · 929 citations · Full text

, , +12

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

Daniel Gallie · Genes & Development · 1991 · 858 citations · Full text

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

Andrew Y. Choo, Sang-Oh Yoon, Sang Gyun Kim et al. · Proceedings of the National Academy of Sciences · 2008 · 794 citations · Full text

, , +17

RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation

Philippe P. Roux, David Shahbazian, Hieu Vu et al. · Journal of Biological Chemistry · 2007 · 758 citations · Full text

, , +12

1–5 of 587

Authors

2.4K

  1. NS
    Nahum Sonenberg

    McGill University, Canada

    53 publications · 9.4K citations

    40

    h-index

  2. ED
    Edward Darżynkiewicz

    University of Warsaw, Poland

    20 publications · 869 citations

    18

    h-index

  3. JP
    Jerry Pelletier

    McGill University, Canada

    17 publications · 1.4K citations

    15

    h-index

  4. WC
    William C. Merrick

    Case Western Reserve University, United States

    14 publications · 1.6K citations

    14

    h-index

  5. JJ
    Jacek Jemielity

    University of Warsaw, Poland

    14 publications · 597 citations

    14

    h-index

1–5 of 2.4K

Institutions

638

  1. McGill University

    Montreal, Canada

    43 h-index

    203 publications

    34.2K citations

  2. University of Warsaw

    Warsaw, Poland

    19 h-index

    126 publications

    5.1K citations

  3. Inserm

    Paris, France

    17 h-index

    80 publications

    9.8K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    78 publications

    4.3K citations

  5. Harvard University

    Cambridge, United States

    14 h-index

    48 publications

    8K citations

  6. Case Western Reserve University

    Cleveland, United States

    14 h-index

    42 publications

    3.4K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    14 h-index

    31 publications

    3.4K citations

  8. New York University

    New York, United States

    14 h-index

    55 publications

    9.3K citations

1–8 of 638

Venues

  1. Journal of Biological Chemistry

    JBC · 75 publications · 6K citations

    44

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  2. Nucleic Acids Research

    42 publications · 2.4K citations

    32

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  3. Proceedings of the National Academy of Sciences

    PNAS · 31 publications · 5.2K citations

    30

    h-index

  4. Molecular and Cellular Biology

    MCB · 31 publications · 4.7K citations

    28

    h-index

  5. RNA

    26 publications · 1.8K citations

    25

    h-index

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