Concepedia

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Mingjian Lu, Min Wan, Karla F. Leavens, Qingwei Chu, Bobby R. Monks, Sully Fernandez, Rexford S. Ahima, Kohjiro Ueki, C. Ronald Kahn, Morris J. Birnbaum

Nature Medicine · 2012 · 390 citations · 50 references

DOI

Concepts

References

50

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Anne Brunet, Azad Bonni, Michael J. Zigmond et al. · Cell · 1999 · 6.6K citations · Full text

, , +13

Insulin signalling and the regulation of glucose and lipid metabolism

Alan R. Saltiel, C. Ronald Kahn · Nature · 2001 · 5.3K citations · Full text

, , +14

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Ken Inoki, Yong Li, Tianquan Zhu et al. · Nature Cell Biology · 2002 · 3.1K citations

, , +6

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Dario R. Alessi, Stephen R. James, C. Peter Downes et al. · Current Biology · 1997 · 2.8K citations · Full text

, , +12

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

Katrin Düvel, Jessica L. Yecies, Suchithra Menon et al. · Molecular Cell · 2010 · 2K citations · Full text

, , +13