Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Han Cho, James Mu, Jason K. Kim, +7

Science

Metabolic DisorderHomeostatic MechanismGlucose HomeostasisInsulin SignalingMetabolic Syndrome +18

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

Han Cho, Joanne L. Thorvaldsen, Qingwei Chu, +2

Journal of Biological Chemistry

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Russell Miller, Qingwei Chu, Jianxin Xie, +3

Nature

Molecular PhysiologySignal TransductionG Protein-coupled ReceptorMedicineLiver Physiology +9

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

Cholsoon Jang, Sungwhan F. Oh, Shogo Wada, +21

Nature Medicine

Insulin ResistanceMetabolic SyndromeBiochemistryPhysiologyDiabetes +7

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

Michael D. Neinast, Cholsoon Jang, Sheng Hui, +9

Cell Metabolism

Energy MetabolismBiochemistryProtein FoldingMedicineCatabolism +7

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

Mingjian Lu, Min Wan, Karla F. Leavens, +7

Nature Medicine

Metabolic SyndromeHepatologyBiochemistryLiver PhysiologyPhysiology +9

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

Paul M. Titchenell, William J. Quinn, Mingjian Lu, +8

Cell Metabolism

Metabolic SyndromeInsulin SignalingIs DispensableHepatologyLiver Physiology +11

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

Russell Miller, Qingwei Chu, John Le Lay, +6

Journal of Clinical Investigation

AdipokinesInsulin SignalingObesityMetabolic SyndromeGluconeogenic Gene Expression +23

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

Paul M. Titchenell, Qingwei Chu, Bobby R. Monks, +1

Nature Communications

NAD precursors cycle between host tissues and the gut microbiome

Karthikeyani Chellappa, Melanie R. McReynolds, Wenyun Lu, +17

Cell Metabolism

BiologyDysbiosisMicrobiotaGut MicrobiologyGut-organ Axis +9