Concepedia

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

Russell Miller, Qingwei Chu, Jianxin Xie, Marc Foretz, Benoı̂t Viollet, Morris J. Birnbaum

Nature · 2013 · 827 citations · 24 references

DOI

Concepts

References

24

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.4K citations

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Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy

David M. Nathan, John B. Buse, Mayer B. Davidson et al. · Diabetes Care · 2008 · 3.8K citations · Full text

, , +17

Mechanisms of fatty acid-induced inhibition of glucose uptake.

Journal of Clinical Investigation · 1994 · 3.5K citations · Full text

, , +17

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

, , +17

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw, Katja Lamia, Debbie S. Vasquez et al. · Science · 2005 · 1.9K citations

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