Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Minoru Yoshida, Masako Kijima, Motomu Akita et al. · Journal of Biological Chemistry · 1990 · 1.9K citations · Full text

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Michael S. Finnin, Jill R. Donigian, Alona Cohen et al. · Nature · 1999 · 1.7K citations

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A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

Victoria M. Richon, Stéphane Emiliani, Eric Verdin et al. · Proceedings of the National Academy of Sciences · 1998 · 914 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +12

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

Ryohei Furumai, Akihisa Matsuyama, Nobuyuki Kobashi et al. · PubMed · 2002 · 744 citations

Life Sciences, Medicinal Chemistry, Pharmacology +13

Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

John R. Somoza, R.J. Skene, B.A. Katz et al. · Structure · 2004 · 698 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +9