Identification of Conserved Pathways of DNA-Damage Response and Radiation Protection by Genome-Wide RNAi

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

Ravi S. Kamath, Andrew Fraser, Dong Yan et al. · Nature · 2003 · 3.7K citations

Life Sciences, Genetics, Molecular Genetics +12

Creation of human tumour cells with defined genetic elements

William C. Hahn, Christopher M. Counter, Ante S. Lundberg et al. · Nature · 1999 · 2.3K citations

Medicine, Cancer Biology, Genetics +13

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

Katrien Berns, E. Marielle Hijmans, Jasper Mullenders et al. · Nature Cell Biology · 2004 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +14

Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis

Qing Zhong, Wenhua Gao, Fenghe Du et al. · Cell · 2005 · 833 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

Meiotic Recombination in C. elegans Initiates by a Conserved Mechanism and Is Dispensable for Homologous Chromosome Synapsis

Abby F. Dernburg, Kent McDonald, Gary Moulder et al. · Cell · 1998 · 799 citations · Full text

Life Sciences, Biology, Genetics +17