A large-scale RNAi screen in human cells identifies new components of the p53 pathway

Katrien Berns, E. Marielle Hijmans, Jasper Mullenders, +13

Nature Cell Biology

Large-scale Rnai ScreenNatural SciencesMolecular BiologyNew ComponentsSmall Rna +5

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

Bryan H. King, Thomas Trimarchi, Linsey B. Reavie, +11

Cell

Hematological MalignancyChromatinTranscriptional RegulationCell RegulationMyc Stability +6

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

Panagiotis Ntziachristos, Aristotelis Tsirigos, G. Grant Welstead, +23

Nature

Histone ModificationsChromatinTumor BiologyAcute Lymphoblastic LeukaemiaHematological Malignancy +12

Mouse and human urothelial cancer organoids: A tool for bladder cancer research

Jasper Mullenders, Evelien de Jongh, Anneta Brousali, +8

Proceedings of the National Academy of Sciences

A Genetic Screen Identifies PITX1 as a Suppressor of RAS Activity and Tumorigenicity

Ingrid Kolfschoten, Bart van Leeuwen, Katrien Berns, +5

Cell

Tumor BiologyRas ActivityMalignant DiseaseMedicinePathology +5

TET1 is a tumor suppressor of hematopoietic malignancy

Luisa Cimmino, Meelad M. Dawlaty, Delphine Ndiaye‐Lobry, +16

Nature Immunology

Hematological MalignancyMalignant Blood DisorderPathologyTumor SuppressorAdult T-cell Leukemia-lymphoma +3

CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank

Maarten H. Geurts, Eyleen de Poel, Gimano D. Amatngalim, +20

Cell stem cell

EngineeringMedicineGeneticsSynthetic BiologyGenetic Engineering +8

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

Thijn R. Brummelkamp, Armida W. M. Fabius, Jasper Mullenders, +5

Nature Chemical Biology

Shrna Barcode ScreenMdm2 InhibitorsMedicineCancer GenomicsLong Non-coding Rna +9

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

Jasper Mullenders, Beatriz Aranda-Orgillés, Priscillia Lhoumaud, +14

The Journal of Experimental Medicine

Mixed-phenotype Acute LeukemiaImmunologyEpigeneticsTumor BiologyMyeloid Neoplasia +16

A Large Scale shRNA Barcode Screen Identifies the Circadian Clock Component ARNTL as Putative Regulator of the p53 Tumor Suppressor Pathway

Jasper Mullenders, Armida W. M. Fabius, Mandy Madiredjo, +2

PLoS ONE