Concepedia

Publication | Open Access

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia

DOIFull Paper Access

124

Citations

49

References

2012

Year

Linda Zuurbier, Emanuel F. Petricoin, Maartje Vuerhard, Valerie Calvert, Clarissa Kooi, Jessica G. C. A. M. Buijs-Gladdines, Willem K. Smits, Edwin Sonneveld, A. Veerman, W. A. Kamps,
Haematologica

Abstract

PI3K/AKT pathway aberrations are present in 18% of pediatric T-cell acute lymphoblastic leukemia patients. Absence of strong NOTCH1-activating mutations in these cases may explain cellular insensitivity to γ-secretase inhibitors.

References

YearCitations

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