Concepedia

Secondary Mutations

Secondary Mutations is a genetic alteration that emerges in a tumor following initial treatment, distinguished from primary mutations by arising as an adaptive response to therapeutic pressure and contributing to acquired resistance.

490

Publications

43.5K

Citations

4K

Authors

1.1K

Institutions

Publications per year

2017–2026

170

Variants

Acquired Mutations

Parents

Publications

490

UPDATE ON DRUG RESISTANCE MUTATIONS IN HIV-1

&NA; · Infectious Diseases in Clinical Practice · 2001 · 1.7K citations

, , +17

Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

Ryohei Katayama, Alice T. Shaw, Tahsin Khan et al. · Science Translational Medicine · 2012 · 1.3K citations

, , +17

EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors

Young Lim Choi, Manabu Soda, Yoshihiro Yamashita et al. · New England Journal of Medicine · 2010 · 1.2K citations · Full text

, , +17

Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in <i>ALK</i> -Rearranged Lung Cancer

Justin F. Gainor, Leila Dardaei, Satoshi Yoda et al. · Cancer Discovery · 2016 · 1.1K citations · Full text

, , +10

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

Wataru Sakai, Elizabeth M. Swisher, Beth Y. Karlan et al. · Nature · 2008 · 1.1K citations · Full text

, , +13

1–5 of 490

Authors

4K

  1. MC
    Michael C. Heinrich

    Oregon Health & Science University, United States

    17 publications · 2.8K citations

    16

    h-index

  2. JA
    Jonathan A. Fletcher

    Brigham and Women's Hospital, United States

    13 publications · 2.5K citations

    12

    h-index

  3. PS
    Patrick Schöffski

    KU Leuven, Belgium

    10 publications · 377 citations

    10

    h-index

  4. RG
    Robert G. Maki

    Memorial Sloan Kettering Cancer Center, United States

    10 publications · 2.7K citations

    10

    h-index

  5. SB
    Sebastian Bauer

    University of Duisburg-Essen, Germany

    9 publications · 629 citations

    9

    h-index

1–5 of 4K

Institutions

1.1K

  1. Memorial Sloan Kettering Cancer Center

    New York, United States

    22 h-index

    125 publications

    28.5K citations

  2. Harvard University

    Cambridge, United States

    21 h-index

    79 publications

    19.7K citations

  3. Brigham and Women's Hospital

    Boston, United States

    19 h-index

    140 publications

    27.2K citations

  4. Dana-Farber Cancer Institute

    Boston, United States

    17 h-index

    100 publications

    18.2K citations

  5. Massachusetts General Hospital

    Boston, United States

    15 h-index

    145 publications

    65.3K citations

  6. KU Leuven

    Leuven, Belgium

    14 h-index

    96 publications

    3.7K citations

  7. Oregon Health & Science University

    Portland, United States

    13 h-index

    99 publications

    26K citations

  8. Inserm

    Paris, France

    12 h-index

    52 publications

    5K citations

1–8 of 1.1K

Venues

  1. Clinical Cancer Research

    27 publications · 6.7K citations

    25

    h-index

  2. Cancer Research

    30 publications · 2.9K citations

    24

    h-index

  3. Journal of Clinical Oncology

    22 publications · 4K citations

    17

    h-index

  4. Journal of Bacteriology

    JB · 19 publications · 1K citations

    15

    h-index

  5. PLoS ONE

    16 publications · 531 citations

    14

    h-index

1–5