Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

Ryohei Katayama, Alice T. Shaw, Tahsin Khan, +13

Science Translational Medicine

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen, +40

Nature Chemical Biology

A genetic mechanism for Tibetan high-altitude adaptation

Felipe Lorenzo, Chad D. Huff, Mikko Myllymäki, +20

Nature Genetics

Molecular EcologyFitnessMedicineGeneticsEvolutionary Biology +7

Acquired Resistance to Crizotinib from a Mutation in <i>CD74</i>–<i>ROS1</i>

Mark M. Awad, Ryohei Katayama, Michele McTigue, +19

New England Journal of Medicine

Genome InstabilitySame Resistance MutationOncogenic AgentMedicineGenetics +12

Two Novel ALK Mutations Mediate Acquired Resistance to the Next-Generation ALK Inhibitor Alectinib

Ryohei Katayama, Luc Friboulet, Sumie Koike, +10

Clinical Cancer Research

Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo

James M. Harris, Virginie Esain, Gregory M. Frechette, +16

Blood

Polymorphism Analysis Reveals Reduced Negative Selection and Elevated Rate of Insertions and Deletions in Intrinsically Disordered Protein Regions

Tahsin Khan, Gavin M. Douglas, Priyenbhai Patel, +2

Genome Biology and Evolution

Differential priority effects impact taxonomy and functionality of host‐associated microbiomes

Jadranka Nappi, Priscila Gonçalves, Tahsin Khan, +5

Molecular Ecology

DysbiosisHost-microbe InteractionsPriority EffectPhylogenetic AnalysisMicrobial Ecology +17

Vincristine and bortezomib cause axon outgrowth and behavioral defects in larval zebrafish

Tahsin Khan, Nathan Benaich, Clare F. Malone, +5

Journal of the Peripheral Nervous System

GeneticsVincristine SulfatePharmacotherapyPeripheral NervesExperimental Pharmacology +18

Genetic testing for Lynch syndrome in the province of Ontario

Marina Wang, Saud H. AlDubayan, Ashton A. Connor, +12

Cancer