Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

Wataru Sakai, Elizabeth M. Swisher, Beth Y. Karlan, +9

Nature

Cisplatin ResistanceSomatic VariantTumor HeterogeneitySecondary MutationsMedicine +8

Secondary Somatic Mutations Restoring<i>BRCA1/2</i>Predict Chemotherapy Resistance in Hereditary Ovarian Carcinomas

Barbara M. Norquist, Kaitlyn Wurz, Christopher C. Pennil, +6

Journal of Clinical Oncology

Secondary <i>BRCA1</i> Mutations in <i>BRCA1</i> -Mutated Ovarian Carcinomas with Platinum Resistance

Elizabeth M. Swisher, Wataru Sakai, Beth Y. Karlan, +3

Cancer Research

Functional Restoration of BRCA2 Protein by Secondary <i>BRCA2</i> Mutations in <i>BRCA2</i> -Mutated Ovarian Carcinoma

Wataru Sakai, Elizabeth M. Swisher, Céline Jacquemont, +7

Cancer Research

Genetic dissection of vertebrate 53BP1: A major role in non-homologous end joining of DNA double strand breaks

Kyoko Nakamura, Wataru Sakai, Takuo Kawamoto, +4

DNA repair

ChromatinGenome InstabilityGeneticsGenetic DissectionMolecular Biology +5

FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair

Junya Unno, Akiko Itaya, Masato Taoka, +9

Cell Reports

The Epistatic Relationship between BRCA2 and the Other RAD51 Mediators in Homologous Recombination

Yong Qing, Mitsuyoshi Yamazoe, Kouji Hirota, +6

PLoS Genetics

GeneticsMolecular BiologyCell DeathMolecular GeneticsBrca2-null Mutant Cells +14

Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein

S. Matsumoto, Eric S. Fischer, Takeshi Yasuda, +9

Nucleic Acids Research

Structure-function analysis of the EF-hand protein centrin-2 for its intracellular localization and nucleotide excision repair

Ryotaro Nishi, Wataru Sakai, Daisuke Tone, +2

Nucleic Acids Research

Molecular BiologyCytoskeletonComplex FormationEndocytic PathwayMulti-protein Assembly +17

SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair

Masaki Akita, Yon-Soo Tak, Tsutomu Shimura, +11

Scientific Reports