Concepedia

Discovery and structure–activity relationships of a novel class of quinazoline glucokinase activators

Tomoharu Iino, Yasuhiro Sasaki, Makoto Bamba, Morihiro Mitsuya, Akio Ohno, Kenji Kamata, Hideka Hosaka, Hiroko Maruki, Mayumi Futamura, Riki Yoshimoto,

Bioorganic & Medicinal Chemistry Letters · 2009 · 42 citations · 15 references

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References

15

Solubility and partitioning I: Solubility of nonelectrolytes in water

Samuel H. Yalkowsky, Shri C. Valvani · Journal of Pharmaceutical Sciences · 1980 · 575 citations

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Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

Joseph Grimsby, Ramakanth Sarabu, Wendy L. Corbett et al. · Science · 2003 · 537 citations

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Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase

Kenji Kamata, Morihiro Mitsuya, T. Nishimura et al. · Structure · 2004 · 503 citations · Full text

, , +16

An Allosteric Activator of Glucokinase Impairs the Interaction of Glucokinase and Glucokinase Regulatory Protein and Regulates Glucose Metabolism

Mayumi Futamura, Hideka Hosaka, Akito Kadotani et al. · Journal of Biological Chemistry · 2006 · 101 citations · Full text

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Design of a potent, soluble glucokinase activator with excellent in vivo efficacy

Darren McKerrecher, Joanne V. Allen, Peter W. R. Caulkett et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 85 citations · Full text

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