A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

Gina M. Doody, Louis B. Justement, Catherine C. Delibrias, +4

Science

Adaptive Immune SystemImmunologyB Cell ActivationImmunologic MechanismCd4 T Cell Responses +16

Hyperresponsive B Cells in CD22-Deficient Mice

Theresa L. O’Keefe, Gareth T. Williams, Sarah L. Davies, +1

Science

Autoimmune DiseaseAdaptive Immune SystemHyperresponsive B CellsImmunologyImmunologic Mechanism +11

CD22 is a negative regulator of B-cell receptor signalling

Lars Nitschke, Rita Carsetti, Bettina Ocker, +2

Current Biology

ImmunologyB-cell ReceptorImmunologic MechanismAutoimmunitySelf-tolerance +3

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

Shinichi Sato, Ann S. Miller, Makoto Inaoki, +4

Immunity

Negative RegulatorAltered SignalingLymphocyte DevelopmentAdaptive Immune SystemImmunology +8

Polygenic Autoimmune Traits: Lyn, CD22, and SHP-1 Are Limiting Elements of a Biochemical Pathway Regulating BCR Signaling and Selection

Richard J. Cornall, Jason G. Cyster, Margaret L. Hibbs, +4

Immunity

Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily

Sørge Kelm, Andrea Pelz, Roland Schauer, +8

Current Biology

Myelin-associated GlycoproteinNew FamilySignal TransductionAutoimmune DiseaseMedicine +10

CD22 regulates thymus-independent responses and the lifespan of B cells

Kevin L. Otipoby, Kristin B. Andersson, Kevin E. Draves, +6

Nature

Autoimmune DiseaseAdaptive Immune SystemImmunologyB CellsAutoimmunity +7

Immune regulation by the ST6Gal sialyltransferase

Thierry Hennet, Daniel Chui, James C. Paulson, +1

Proceedings of the National Academy of Sciences

Deficiency in CD22, a B Cell–specific Inhibitory Receptor, Is Sufficient to Predispose to Development of High Affinity Autoantibodies

Theresa L. O’Keefe, Gareth T. Williams, Facundo D. Batista, +1

The Journal of Experimental Medicine

High Affinity AutoantibodiesB Cell HyperresponsivenessImmune RegulationImmunologyImmunodominance +21

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

Deborah J. Lenschow, Anne I. Sperling, Michael P. Cooke, +7

The Journal of Immunology

Ag-pulsed B CellsAdaptive Immune SystemImmune RegulationImmunologyImmunologic Mechanism +19