Assessing the chemical diversity of an hsp90 database

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

Adeela Kamal, Lia Thao, John Sensintaffar et al. · Nature · 2003 · 1.4K citations

Medicine, Oncology, Pharmacology +10

Chemical space and biology

Christopher M. Dobson · Nature · 2004 · 1K citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +14

RECAPRetrosynthetic Combinatorial Analysis Procedure:  A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry

Xiao Qing Lewell, Duncan B. Judd, Michael M. Hann · Journal of Chemical Information and Computer Sciences · 1998 · 701 citations

Pharmacy, Medicinal Chemistry, Combinatorial Chemistry +13

Novobiocin and Related Coumarins and Depletion of Heat Shock Protein 90-Dependent Signaling Proteins

Monica G. Marcu, T W Schulte, Leonard Μ. Neckers · JNCI Journal of the National Cancer Institute · 2000 · 404 citations

Medicine, Molecular Biology, Pharmacology +12

Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design

Brian Dymock, Xavier Barril, Paul A. Brough et al. · Journal of Medicinal Chemistry · 2005 · 231 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15