Concepedia

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

T Blunt, Nicholas Finnie, Guillermo E. Taccioli, Graeme C.M. Smith, Jocelyne Demengeot, Tanya Gottlieb, Ryushin Mizuta, A. J. Varghese, Frederick W. Alt, Penny A. Jeggo,

Cell · 1995 · 865 citations · 45 references

Open access

Concepts

Life SciencesGeneticsMolecular BiologyDna RepairRecombinationDna DamageDna Double-strand Break RepairDna Repair DefectsHomologous RecombinationRecombination ProteinsV(d)j RecombinationDefective Dna Repair PathwaysDna Repair Pathway DefectsDna-pk - Mediated RecombinationHomologous Recombination DeficiencyV(d)j Recombination DefectsV(d)j Recombination Errors

References

45

RAG-1-deficient mice have no mature B and T lymphocytes

Peter Mombaerts, John Iacomini, Randall S. Johnson et al. · Cell · 1992 · 2.9K citations

Life Sciences, Genetics, Immunology +13

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Yoichi Shinkai · Cell · 1992 · 2.6K citations

Life Sciences, Genetics, Immunology +14

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

Marjorie A. Oettinger, David G. Schatz, Carolyn Gorka et al. · Science · 1990 · 1.5K citations

Life Sciences, Genetics, Molecular Genetics +17

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Tanya Gottlieb, Stephen P. Jackson · Cell · 1993 · 1.2K citations

Life Sciences, Genetics, Molecular Biology +14

O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation

Stephen P. Jackson, Robert Tjian · Cell · 1988 · 902 citations

Life Sciences, Biochemistry, Molecular Biology +14