Graeme C.M. Smith

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord et al. · Nature · 2005 · 6.5K citations

Genome Instability, Dna Damage, Brca Mutant Cells +7

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

Nuala McCabe, Nicholas C. Turner, Christopher J. Lord et al. · Cancer Research · 2006 · 1.3K citations

Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

Ian Hickson, Yan Zhao, Caroline J. Richardson et al. · Cancer Research · 2004 · 1.2K citations

Specific Inhibitor, Molecular Biology, Cell Cycle +16

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

Ali Jazayeri, Jacob Falck, Claudia Lukas et al. · Nature Cell Biology · 2005 · 1K citations

Chromatin, Genome Instability, Transcriptional Regulation +13

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

T Blunt, Nicholas Finnie, Guillermo E. Taccioli et al. · Cell · 1995 · 864 citations · Full text

Murine Scid Mutation, Genome Instability, J Recombination +12