Concepedia

V(d)j Recombination Errors

V(D)J Recombination Errors is a biological phenomenon characterized by aberrant genetic rearrangements during the V(D)J recombination process that deviate from the canonical assembly of immunoglobulin or T-cell receptor genes, leading to nonfunctional or autoreactive lymphocyte receptors.

40

Publications

5.5K

Citations

220

Authors

85

Institutions

Publications per year

2017–2026

5

Parents

Publications

40

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

T Blunt, Nicholas Finnie, Guillermo E. Taccioli et al. · Cell · 1995 · 865 citations · Full text

, , +14

Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

Karen M. Frank, JoAnn Sekiguchi, Katherine J. Seidl et al. · Nature · 1998 · 588 citations

, , +17

V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

David B. Roth, Joseph P. Menetski, Pamela B. Nakajima et al. · Cell · 1992 · 447 citations

, , +15

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

Chengming Zhu, Molly A. Bogue, Dae‐Sik Lim et al. · Cell · 1996 · 430 citations · Full text

, , +14

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

Anna Villa · Blood · 2001 · 346 citations · Full text

, , +17

1–5 of 40

Authors

220

  1. FW
    Frederick W. Alt

    Howard Hughes Medical Institute, United States

    5 publications · 2K citations

    5

    h-index

  2. EA
    Eric A. Hendrickson

    University of Minnesota Medical Center, United States

    4 publications · 96 citations

    4

    h-index

  3. MG
    Martin Gellert

    National Institutes of Health, United States

    4 publications · 998 citations

    4

    h-index

  4. MR
    Michael R. Lieber

    University of Southern California, United States

    3 publications · 215 citations

    3

    h-index

  5. DC
    Dik C. van Gent

    Erasmus MC, Netherlands

    2 publications · 323 citations

    2

    h-index

1–5 of 220

Institutions

85

  1. National Institutes of Health

    Bethesda, United States

    6 h-index

    14 publications

    3.3K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    29 publications

    6.8K citations

  3. Harvard University

    Cambridge, United States

    4 h-index

    19 publications

    8.1K citations

  4. Brown University

    Providence, United States

    4 h-index

    9 publications

    256 citations

  5. University of Southern California

    Los Angeles, United States

    3 h-index

    6 publications

    393 citations

  6. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    3 h-index

    10 publications

    2.9K citations

  7. The Gurdon Institute

    Cambridge, United Kingdom

    2 h-index

    3 publications

    899 citations

  8. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    7 publications

    4.4K citations

1–8 of 85

Venues

  1. Cell

    5 publications · 2.2K citations

    5

    h-index

  2. Blood

    4 publications · 645 citations

    4

    h-index

  3. Journal of Biological Chemistry

    JBC · 3 publications · 243 citations

    3

    h-index

  4. Molecular Immunology

    3 publications · 95 citations

    3

    h-index

  5. Molecular Cell

    3 publications · 565 citations

    3

    h-index

1–5