Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Functional significance of a C→A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

Christoph Sachse, Jürgen Brockmöller, Steffen Bauer et al. · British Journal of Clinical Pharmacology · 1999 · 750 citations · Full text

Life Sciences, Genetics, Pharmacology +14

Coffee, CYP1A2 Genotype, and Risk of Myocardial Infarction

Marilyn C. Cornelis, Ahmed El‐Sohemy, Edmond K. Kabagambe et al. · JAMA · 2006 · 488 citations · Full text

Medicine, Cardiology, Pharmacology +17

Genetic Polymorphism in the 5'-Flanking Region of HumanCYP1A2 Gene: Effect on the CYP1A2 Inducibility in Humans

Mitsutoshi Nakajima, Tsuyoshi Yokoi, Mayumi Mizutani et al. · The Journal of Biochemistry · 1999 · 347 citations

Medicine, Molecular Genetics, Pharmacology +12

Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.

Leif Bertilsson, JA Carrillo, M-L Dahl et al. · British Journal of Clinical Pharmacology · 1994 · 308 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15