Dendritic cells lentivirally engineered to overexpress interleukin‐10 inhibit contact hypersensitivity responses, despite their partial activation induced by transduction‐associated physical stress

Abstract

Lentiviral transduction of BM-DCs results in their partial activation. Nevertheless, the transduction of these DCs with a vector encoding the immunomodulatory cytokine IL-10 rendered them tolerogenic. Thus, lentivirally-transduced DCs expressing immunomodulatory molecules represent a promising tool for induction of tolerance.