Concepedia

Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist ‘CJ-17,493’

Yuji Shishido, H. Wakabayashi, Hiroki Koike, Naomi Ueno, Seiji Nukui, Tatsuya Yamagishi, Yoshinori Murata, Fumiharu Naganeo, Mayumi Mizutani, Kaoru Shimada,

Bioorganic & Medicinal Chemistry · 2008 · 66 citations · 14 references

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References

14

A Potent Nonpeptide Antagonist of the Substance P (NK <sub>1</sub> ) Receptor

R. Michael Snider, Jay W. Constantine, John Lowe et al. · Science · 1991 · 864 citations

, , +14

Synthetic methods and reactions. 141. Fluoride-induced trifluoromethylation of carbonyl compounds with trifluoromethyltrimethylsilane (TMS-CF3). A trifluoromethide equivalent

G. K. Surya Prakash, Ramesh Krishnamurti, George A. Olah · Journal of the American Chemical Society · 1989 · 529 citations

, , +4

Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK <sub>1</sub> ) Receptor Antagonist

Stafford McLean, Alan H. Ganong, Thomas Seeger et al. · Science · 1991 · 218 citations

, , +17

Structural Optimization Affording 2-(<i>R</i>)-(1-(<i>R</i>)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(<i>S</i>)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Jeffrey J. Hale, Sander G. Mills, Malcolm MacCoss et al. · Journal of Medicinal Chemistry · 1998 · 205 citations · Full text

, , +15

Process Research and Development of an NK-1 Receptor Antagonist. Enantioselective Trifluoromethyl Addition to a Ketone in the Preparation of a Chiral Isochroman

Stéphane Caron, Nga M., Janice E. Sieser et al. · Organic Process Research & Development · 2007 · 95 citations

, , +13