Concepedia

The involvement of p62–Keap1–Nrf2 antioxidative signaling pathway and JNK in the protection of natural flavonoid quercetin against hepatotoxicity

Lili Ji, Yuchen Sheng, Zhiyong Zheng, Liang Shi, Zhengtao Wang

Free Radical Biology and Medicine · 2015 · 168 citations · 25 references

DOI

Concepts

References

25

Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study

M.G.L Hertog, Edith J. M. Feskens, Daan Kromhout et al. · The Lancet · 1993 · 4.4K citations · Full text

, , +16

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

Morten Hansen, Svend Erik Nielsen, Kurt Berg · Journal of Immunological Methods · 1989 · 3.5K citations

, , +11

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Masaaki Komatsu, Satoshi Waguri, Keiko Taguchi et al. · Nature Cell Biology · 2010 · 2.4K citations

, , +14

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi, Moon-Il Kang, Hiromi Okawa et al. · Molecular and Cellular Biology · 2004 · 2.2K citations · Full text

, , +17

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Ashish Jain, Trond Lamark, Eva Sjøttem et al. · Journal of Biological Chemistry · 2010 · 1.5K citations · Full text

, , +17