Concepedia

Synthesis and release of doxorubicin from a cephalosporin based prodrug by a β-lactamase-immunoconjugate

Thomas W. Hudyma, Karen Bush, Kimberly L. Colson, Raymond A. Firestone, Dalton King

Bioorganic & Medicinal Chemistry Letters · 1993 · 30 citations · 9 references

DOI

Concepts

References

9

A cytotoxic agent can be generated selectively at cancer sites

K D Bagshawe, Springer Cj, F Searle et al. · British Journal of Cancer · 1988 · 265 citations · Full text

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New hydrazone derivatives of Adriamycin and their immunoconjugates - a correlation between acid stability and cytotoxicity

Takushi Kaneko, David Willner, Ivo Monković et al. · Bioconjugate Chemistry · 1991 · 162 citations

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Mechanism of inhibition of the PC1 .beta.-lactamase of Staphylococcus aureus by cephalosporins: importance of the 3'-leaving group

W. Stephen Faraci, R. F. Pratt · Biochemistry · 1985 · 77 citations

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Cephalosporin Nitrogen Mustard Carbamate prodrugs for “ADEPT”.

Rikki Alexander, Nigel R. A. Beeley, Faye P. O'Neill et al. · Tetrahedron Letters · 1991 · 62 citations

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A novel targeted delivery system utilizing a cephalosporin-oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer

Timothy A. Shepherd, Louis N. Jungheim, Damon L. Meyer et al. · Bioorganic & Medicinal Chemistry Letters · 1991 · 56 citations

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