Nigel R. A. Beeley

Discovery and Structure−Activity Relationship of (1<i>R</i>)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1<i>H</i>-3-benzazepine (Lorcaserin), a Selective Serotonin 5-HT_2C Receptor Agonist for the Treatment of Obesity

Brian M. Smith, Jeffrey M. Smith, James H. Tsai et al. · Journal of Medicinal Chemistry · 2007 · 202 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

Brian M. Smith, Jeffrey M. Smith, James H. Tsai et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Synthesis of C- and N-functionalised derivatives of 1,4,7-triazacyclononane-1,4,7-triyltriacetic acid (NOTA), 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetrayltetra-acetic acid (DOTA), and diethylenenetriaminepenta-acetic acid (DTPA): bifunctional complexing agents for the derivatisation of antibodies

J. P. Cox, Andrew S. Craig, I. M. HELPS et al. · Journal of the Chemical Society Perkin Transactions 1 · 1990 · 79 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Synthesis of a kinetically stable yttrium-90 labelled macrocycle–antibody conjugate

J. P. Cox, Karl J. Jankowski, Ritu Kataky et al. · Journal of the Chemical Society Chemical Communications · 1989 · 77 citations

Pharmacy, Biochemistry, Monoclonal Antibodies +13

The in vivo release of 90Y from cyclic and acyclic ligand-antibody conjugates

A. Harrison, Carole A. Walker, David Parker et al. · International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology · 1991 · 72 citations

Pharmacy, Medicinal Chemistry, Pharmacokinetics +14