F Searle

A cytotoxic agent can be generated selectively at cancer sites

K D Bagshawe, Springer Cj, F Searle et al. · British Journal of Cancer · 1988 · 265 citations · Full text

Tumor Biology, Oncology, Oncogenic Agent +7

Polymer–drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic

Ruth Duncan, S. Gac-Breton, R. Keane et al. · Journal of Controlled Release · 2001 · 194 citations

Medicinal Chemistry, Pharmaceutical Science, Engineering +9

Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2

Caroline J. Springer, Pari Antoniw, Bagshawe et al. · Journal of Medicinal Chemistry · 1990 · 134 citations

Carboxypeptidase G2, Medicinal Chemistry, Biochemistry +14

Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds

Caroline J. Springer, Kenneth D. Bagshawe, Surinder K. Sharma et al. · European Journal of Cancer and Clinical Oncology · 1991 · 116 citations

Novel Compounds, Drug Targeting, Nude Mice +9

LIPOSOMALLY ENTRAPPED SECOND ANTIBODY IMPROVES TUMOUR IMAGING WITH RADIOLABELLED (FIRST) ANTITUMOUR ANTIBODY

Richard H. J. Beǵent, A.J Green, K D Bagshawe et al. · The Lancet · 1982 · 109 citations

Oncologic Imaging, Medicine, Antitumour Antibody +9