Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia

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Medicine, Cancer Biology, Oncology +14

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent <i>in vivo</i> antitumor activity

Sauveur-Michel Maira, Frédéric Stauffer, Josef Brueggen et al. · Molecular Cancer Therapeutics · 2008 · 1.1K citations · Full text

Medicine, Oncology, Pharmacology +13

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

Violeta Serra, Ben Markman, Maurizio Scaltriti et al. · Cancer Research · 2008 · 796 citations · Full text

Medicine, Oncology, Pharmacology +16

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

Qi-Wen Fan, Zachary A. Knight, David Goldenberg et al. · Cancer Cell · 2006 · 584 citations · Full text

Medicine, Neuroscience, Oncology +10

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Beth Apsel, Jimmy A. Blair, Beatriz González et al. · Nature Chemical Biology · 2008 · 439 citations · Full text

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