Concepedia

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

Masanori Miwa, Masako Ura, M Nishida, Noriaki Sawada, T Ishikawa, Kazushige Mori, Nobuo Shimma, Isao UMEDA, Hideo Ishitsuka

European Journal of Cancer · 1998 · 1.2K citations · 14 references

DOI

Concepts

References

14

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

, , +14

Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma

Y. Takebayashi, Shin‐ichi Akiyama, Suminori Akiba et al. · JNCI Journal of the National Cancer Institute · 1996 · 366 citations

, , +14

Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts.

Tohru Ishikawa, Fumiko Sekiguchi, Yu Fukase et al. · PubMed · 1998 · 304 citations

, , +16

Expression of platelet‐derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer

Masakazu Toi, Seigo Hosnina, Tadaaki Taniguchi et al. · International Journal of Cancer · 1995 · 162 citations

, , +10

Distribution of kinase and deaminase of 1-beta-D-arabinofuranosylcytosine in tissues of man and mouse.

D H Ho · PubMed · 1973 · 144 citations

, , +7