Isao UMEDA

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

Masanori Miwa, Masako Ura, M Nishida et al. · European Journal of Cancer · 1998 · 1.2K citations

Medicinal Chemistry, Cancer Tissue, Medicine +8

Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: Disulfide bonds boost intracellular release of the cargo

Miriam Breunig, Constantin Hozsa, Uta Lungwitz et al. · Journal of Controlled Release · 2008 · 203 citations

Cell-based Drug Delivery, Nanomedicine, Engineering +9

The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine

Nobuo Shimma, Isao UMEDA, M. Arasaki et al. · Bioorganic & Medicinal Chemistry · 2000 · 135 citations

Medicinal Chemistry, Polymer-drug Conjugate, Medicine +6

Nickel-catalyzed reactions involving strained .sigma. bonds. IV. Nickel(0)-catalyzed reaction of methylenecyclopropane with olefins. Orientation and stereochemistry

R. Noyori, Y. KUMAGAI, Isao UMEDA et al. · Journal of the American Chemical Society · 1972 · 108 citations

Chemical Engineering, Engineering, Alkene Metathesis +9

Selective hydrogenation of .alpha.,.beta.-unsaturated carbonyl compounds via hydridoiron complexes

Ryōji Noyori, Isao UMEDA, T Ishigami · The Journal of Organic Chemistry · 1972 · 102 citations

Selective Hydrogenation, Engineering, Biochemistry +12