Nobuo Shimma

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

Masanori Miwa, Masako Ura, M Nishida et al. · European Journal of Cancer · 1998 · 1.2K citations

Medicinal Chemistry, Cancer Tissue, Medicine +8

Host sphingolipid biosynthesis as a target for hepatitis C virus therapy

Hiroshi Sakamoto, Koichi Okamoto, Masahiro Aoki et al. · Nature Chemical Biology · 2005 · 176 citations · Full text

Biochemistry, Synthetic Virology, Viral Hepatitis +6

Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Nobuya Ishii, Naoki Harada, Eric W. Joseph et al. · Cancer Research · 2013 · 160 citations

Raf Feedback Limits, Raf Activity, Cancer Biology +17

The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine

Nobuo Shimma, Isao UMEDA, M. Arasaki et al. · Bioorganic & Medicinal Chemistry · 2000 · 135 citations

Medicinal Chemistry, Polymer-drug Conjugate, Medicine +6

Crystal Structures of Candida albicans N-Myristoyltransferase with Two Distinct Inhibitors

Satoshi Sogabe, Miyako Masubuchi, Kiyoaki Sakata et al. · Chemistry & Biology · 2002 · 130 citations · Full text

Antifungal Agent, Biochemistry, Natural Sciences +4