Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: Disulfide bonds boost intracellular release of the cargo

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Otmane Boussif, Frank Lezoualc’h, Maria Antonietta Zanta et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

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Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes

N.D. Sonawane, Francis C. Szoka, A.S. Verkman · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +14

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

Beata Urban-Klein, Stephanie Werth, Shaker Abuharbeid et al. · Gene Therapy · 2004 · 707 citations

Pharmacy, Biotechnology, Molecular Biology +14

P-Body Formation Is a Consequence, Not the Cause, of RNA-Mediated Gene Silencing

Ana Eulálio, Isabelle Behm‐Ansmant, Daniel Schweizer et al. · Molecular and Cellular Biology · 2007 · 702 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Disruption of GW bodies impairs mammalian RNA interference

Andrew Jakymiw, Shangli Lian, Theophany Eystathioy et al. · Nature Cell Biology · 2005 · 492 citations

Life Sciences, Genetics, Molecular Biology +10