Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

Masanori Miwa, Masako Ura, M Nishida, +6

European Journal of Cancer

Medicinal ChemistryCancer TissueMedicinePharmacologyHuman Liver +6

XELOX (Capecitabine Plus Oxaliplatin): Active First-Line Therapy for Patients With Metastatic Colorectal Cancer

Jim Cassidy, Josep Tabernero, Chris Twelves, +11

Journal of Clinical Oncology

Induction of thymidine phosphorylase activity and enhancement of capecitabine efficacy by taxol/taxotere in human cancer xenografts.

Noriaki Sawada, T Ishikawa, Yu Fukase, +3

PubMed

Capecitabine EfficacyHuman Cancer XenograftsCancer BiologyWidr CellsTumor Biology +14

Tumor Selective Delivery of 5-Fluorouracil by Capecitabine, a New Oral Fluoropyrimidine Carbamate, in Human Cancer Xenografts

Tohru Ishikawa, Masahiro Utoh, Noriaki Sawada, +4

Biochemical Pharmacology

OncologyPolymer-drug ConjugateMedicineTumor Selective DeliveryPharmacotherapy +8

X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts.

Noriaki Sawada, T Ishikawa, Fumiko Sekiguchi, +2

PubMed

X-ray Irradiation InducesRadiation EffectPathologyHuman Cancer XenograftsRadiation Biology +16

Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts.

Tohru Ishikawa, Fumiko Sekiguchi, Yu Fukase, +2

PubMed

Chemoprevention StrategyPathologyHuman Cancer XenograftsDehydrogenase ActivitiesDthdpase Activity +14

The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine

Nobuo Shimma, Isao UMEDA, M. Arasaki, +10

Bioorganic & Medicinal Chemistry

Medicinal ChemistryPolymer-drug ConjugateMedicineFluorous SynthesisAnti-cancer Agent +4

Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5?-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models

Mika Endo, Noriko Shinbori, Yu Fukase, +4

International Journal of Cancer

Tumor BiologyBreast OncologyOncologyChemoprevention StrategyBiochemistry +13

Anti-GPRC5D/CD3 Bispecific T-Cell–Redirecting Antibody for the Treatment of Multiple Myeloma

Tatsushi Kodama, Yu Kochi, Waka Nakai, +12

Molecular Cancer Therapeutics

The structures of camelliagenin A, B, and C obtained from L.

Hideji Itokawa, Noriaki Sawada, Taro Murakami

Tetrahedron Letters

BiosynthesisBioorganic ChemistryBiochemistryBiochemical TaxonomyNatural Sciences +10