Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

Masanori Miwa, Masako Ura, M Nishida, +6

European Journal of Cancer

Medicinal ChemistryCancer TissueMedicinePharmacologyHuman Liver +6

Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection

Norio Iizuka, Masaaki Oka, Hisafumi Yamada‐Okabe, +14

The Lancet

Surgical OncologyHepatologyHepatocellular CarcinomaMedicineCurative Resection +13

Induction of thymidine phosphorylase activity and enhancement of capecitabine efficacy by taxol/taxotere in human cancer xenografts.

Noriaki Sawada, T Ishikawa, Yu Fukase, +3

PubMed

Capecitabine EfficacyHuman Cancer XenograftsCancer BiologyWidr CellsTumor Biology +14

Tumor Selective Delivery of 5-Fluorouracil by Capecitabine, a New Oral Fluoropyrimidine Carbamate, in Human Cancer Xenografts

Tohru Ishikawa, Masahiro Utoh, Noriaki Sawada, +4

Biochemical Pharmacology

OncologyPolymer-drug ConjugateMedicineTumor Selective DeliveryPharmacotherapy +8

X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts.

Noriaki Sawada, T Ishikawa, Fumiko Sekiguchi, +2

PubMed

X-ray Irradiation InducesRadiation EffectPathologyHuman Cancer XenograftsRadiation Biology +16

Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts.

Tohru Ishikawa, Fumiko Sekiguchi, Yu Fukase, +2

PubMed

Chemoprevention StrategyPathologyHuman Cancer XenograftsDehydrogenase ActivitiesDthdpase Activity +14

Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5?-deoxy-5-fluorouridine

Hiroyuki Eda, Kaori Fujimoto, Shinichi Watanabe, +5

Cancer Chemotherapy and Pharmacology

Cancer ResearchCytokineOncogenic AgentImmunologyCell Death +8

Experimental cancer cachexia induced by transplantable colon 26 adenocarcinoma in mice.

Yutaka Tanaka, Hiroyuki Eda, Takashi Tanaka, +6

PubMed

PathologyMetabolic RemodelingCancer BiologyTumor BiologyMetabolic Syndrome +22

Expression of platelet‐derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer

Masakazu Toi, Seigo Hosnina, Tadaaki Taniguchi, +3

International Journal of Cancer

Antipicornavirus flavone Ro 09-0179

Hideo Ishitsuka, C Ohsawa, Toshio Ohiwa, +2

Antimicrobial Agents and Chemotherapy

Viral ReplicationMolecular VirologyMedicinePathogenesisImmunology +9