Hideo Ishitsuka

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

Masanori Miwa, Masako Ura, M Nishida et al. · European Journal of Cancer · 1998 · 1.2K citations

Medicinal Chemistry, Cancer Tissue, Medicine +8

Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection

Norio Iizuka, Masaaki Oka, Hisafumi Yamada‐Okabe et al. · The Lancet · 2003 · 512 citations

Surgical Oncology, Hepatology, Hepatocellular Carcinoma +15

Induction of thymidine phosphorylase activity and enhancement of capecitabine efficacy by taxol/taxotere in human cancer xenografts.

Noriaki Sawada, T Ishikawa, Yu Fukase et al. · PubMed · 1998 · 425 citations

Capecitabine Efficacy, Human Cancer Xenografts, Cancer Biology +16

Tumor Selective Delivery of 5-Fluorouracil by Capecitabine, a New Oral Fluoropyrimidine Carbamate, in Human Cancer Xenografts

Tohru Ishikawa, Masahiro Utoh, Noriaki Sawada et al. · Biochemical Pharmacology · 1998 · 329 citations

Oncology, Polymer-drug Conjugate, Medicine +10

X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts.

Noriaki Sawada, T Ishikawa, Fumiko Sekiguchi et al. · PubMed · 1999 · 321 citations

X-ray Irradiation Induces, Radiation Effect, Pathology +18