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Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective α2C adrenergic receptor antagonist

Snahel Patel, Wendy M. Habeski, Hyunsuk Min, Jiansu Zhang, Robin L. Roof, Bradley J. Snyder, Gary Bora, Brian Campbell, Cheryl Li, Debra Hidayetoglu,

Bioorganic & Medicinal Chemistry Letters · 2008 · 10 citations · 8 references

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11K citations

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Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada et al. · Pharmaceutical Research · 1999 · 792 citations

Pharmacological characterization and CNS effects of a novel highly selective<i>α</i><sub>2C</sub>‐adrenoceptor antagonist JP‐1302

Jukka Sallinen, Iisa P. J. Höglund, Mia Engström et al. · British Journal of Pharmacology · 2007 · 94 citations · Full text

Evaluation of the α2C-adrenoceptor as a neuropsychiatric drug target

Mika Scheinin, Jukka Sallinen, Antti Haapalinna · Life Sciences · 2001 · 87 citations

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The discovery of a selective, high affinity A2B adenosine receptor antagonist for the potential treatment of asthma

Jeff Zablocki, Rao Kalla, Thao Perry et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 61 citations · Full text

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