Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model

Linus L. Shen, Lester A. Mitscher, Padam N. Sharma et al. · Biochemistry · 1989 · 416 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +16

Routes of quinolone permeation in Escherichia coli

Jack Chapman, N H Georgopapadakou · Antimicrobial Agents and Chemotherapy · 1988 · 250 citations · Full text

Life Sciences, Microbiology, Pharmacology +14

Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships

Paul S. Charifson, Anne‐Laure Grillot, Trudy H. Grossman et al. · Journal of Medicinal Chemistry · 2008 · 225 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Synthesis and in vitro antibacterial evaluation of N-[5-(5-nitro-2-thienyl)-1,3,4-thiadiazole-2-yl] piperazinyl quinolones

Alireza Foroumadi, Shahla Mansouri, Zahra Kiani et al. · European Journal of Medicinal Chemistry · 2003 · 183 citations

Pharmacy, Medicinal Chemistry, Pharmacology +6

Synthesis and antimicrobial activity of thiosemicarbazides, s-triazoles and their Mannich bases bearing 3-chlorophenyl moiety

Tomasz Plech, Monika Wujec, Agata Siwek et al. · European Journal of Medicinal Chemistry · 2010 · 155 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9