Synthesis and antimicrobial activity of thiosemicarbazides, s-triazoles and their Mannich bases bearing 3-chlorophenyl moiety

Tomasz Plech, Monika Wujec, Agata Siwek, +2

European Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryHeterocyclicNatural Sciences3-Chlorophenyl Moiety +6

Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria

Tomasz Plech, Monika Wujec, Urszula Kosikowska, +3

European Journal of Medicinal Chemistry

AntibioticsMedicine1,2,4-Triazole-ciprofloxacin HybridsAntibacterial AgentAntimicrobial Chemotherapy +8

Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles

Tomasz Plech, Jarogniew J. Łuszczki, Monika Wujec, +2

European Journal of Medicinal Chemistry

Medicinal ChemistryOrganic ChemistryPreliminary Anticonvulsant EvaluationHeterocycle ChemistryPharmacology +1

Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies

Barbara Kaproń, Jarogniew J. Łuszczki, Anita Płazińska, +13

European Journal of Pharmaceutical Sciences

NeurophysiologyMedicineAnesthetic MechanismIon ChannelsNeuropharmacology +7

Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids

Tomasz Plech, Barbara Kaproń, Agata Paneth, +7

European Journal of Medicinal Chemistry

Antimicrobial SusceptibilityAntibioticsMedicineAntibacterial Activity1,2,4-Triazole-ciprofloxacin Hybrids +8

Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3-thiones and their effect on GABAergic system

Tomasz Plech, Barbara Kaproń, Jarogniew J. Łuszczki, +5

European Journal of Medicinal Chemistry

Medicinal ChemistryMedicineGabaergic SystemNeuropharmacologyAnticonvulsant Activity +1

1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy

Barbara Kaproń, Robert Czarnomysy, Mariusz Wysokiński, +5

Journal of Enzyme Inhibition and Medicinal Chemistry

Pharmacological StudyMedicineHz ModelNeuropharmacologyPharmacological Agent +12

Studies on the Anticonvulsant Activity and Influence on GABA-ergic Neurotransmission of 1,2,4-Triazole-3-thione- Based Compounds

Tomasz Plech, Barbara Kaproń, Jarogniew J. Łuszczki, +6

Molecules

Psychotropic MedicationPharmacotherapyStructural SimilarityGaba-ergic NeurotransmissionPharmaceutical Chemistry +15

Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells—In Vitro Studies

Katarzyna Walczak, Ewa Langner, Anna Makuch‐Kocka, +4

International Journal of Molecular Sciences

ApoptosisCell DeathTumor BiologyMelanoma CellsTryptophan-derived Ahr Ligands +16

Lichen-Derived Compounds and Extracts as Biologically Active Substances with Anticancer and Neuroprotective Properties

Elżbieta Studzińska-Sroka, Aleksandra Majchrzak‐Celińska, Przemysław Zalewski, +6

Pharmaceuticals