Padam N. Sharma

Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model

Linus L. Shen, Lester A. Mitscher, Padam N. Sharma et al. · Biochemistry · 1989 · 416 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +16

Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)

Lester A. Mitscher, Padam N. Sharma, Daniel T. W. Chu et al. · Journal of Medicinal Chemistry · 1987 · 101 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Synthesis and biological effects of novel thiocolchicines. 3. evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl)deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl- and 3-demethylthiocolchicine

Peter Kerkes, Padam N. Sharma, Arnold Brossi et al. · Journal of Medicinal Chemistry · 1985 · 50 citations

Pharmacy, Medicinal Chemistry, Pharmacology +6

Biological effects of modified colchicines. 2. Evaluation of catecholic colchicines, colchifolines, colchicide, and novel N-acyl- and N-aroyldeacetylcolchicines

Arnold Brossi, Padam N. Sharma, Louise Atwell et al. · Journal of Medicinal Chemistry · 1983 · 39 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Toddasin, a new dimeric coumarin from Toddalia asiatica

Padam N. Sharma, Aboo Shoeb, R. S. Kapil et al. · Phytochemistry · 1980 · 30 citations

Life Sciences, Chemistry, Medicinal Chemistry +8