PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

Thierry Conroy, Françoise Desseigne, Marc Ychou et al. · New England Journal of Medicine · 2011 · 7.8K citations · Full text

Medicine, Oncology, Pharmacology +13

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

Vladimir J.N. Bykov, Natalia Issaeva, Alexandre Shilov et al. · Nature Medicine · 2002 · 1.1K citations

Life Sciences, Molecular Biology, Oncology +13

Pharmacological Rescue of Mutant p53 Conformation and Function

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Medicine, Oncology, Pharmacology +13

Tumor-suppressive pathways in pancreatic carcinoma.

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Medicine, Genetics, Oncology +17

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

Jennifer P. Morton, Paul Timpson, Saadia A. Karim et al. · Proceedings of the National Academy of Sciences · 2009 · 679 citations · Full text

Medicine, Molecular Biology, Oncology +16