Vladimir J.N. Bykov

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

Vladimir J.N. Bykov, Natalia Issaeva, Alexandre Shilov et al. · Nature Medicine · 2002 · 1.1K citations

Tumor Biology, Medicine, Molecular Biology +9

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

Jérémy Lambert, Petr Gorzov, Dmitry B. Veprintsev et al. · Cancer Cell · 2009 · 566 citations

Covalent Binding, Core Domain, Cell Death +6

Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

Sören Lehmann, Vladimir J.N. Bykov, Dina Ali et al. · Journal of Clinical Oncology · 2012 · 397 citations · Full text

PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis

Vladimir J.N. Bykov, Nicole Zache, Hélène Stridh et al. · Oncogene · 2005 · 250 citations

Cell Death, Prima-1met Synergizes, Tumor Suppressor +5

Reactivation of Mutant p53 and Induction of Apoptosis in Human Tumor Cells by Maleimide Analogs

Vladimir J.N. Bykov, Natalia Issaeva, Nicole Zache et al. · Journal of Biological Chemistry · 2005 · 248 citations · Full text

Apoptosis, Cell Death, Molecular Biology +16