PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

Tissue sulfhydryl groups

George L. Ellman · Archives of Biochemistry and Biophysics · 1959 · 25.9K citations

Biochemistry, Glycobiology, Tissue Physiology +3

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

Yunje Cho, Svetlana S. Gorina, Philip D. Jeffrey et al. · Science · 1994 · 2.5K citations

Chromatin, Crystal Structure, Dna Binding +15

A model for p53-induced apoptosis

Kornélia Polyák, Yong Xia, Jay L. Zweíer et al. · Nature · 1997 · 2.5K citations

Medicine, Apoptosis, Cell Death +4

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Wen Xue, Lars Zender, Cornelius Miething et al. · Nature · 2007 · 2.4K citations · Full text

Tumour Clearance, Hepatology, Hepatocellular Carcinoma +13

Restoration of p53 function leads to tumour regression in vivo

Andrea Ventura, David G. Kirsch, Margaret E. McLaughlin et al. · Nature · 2007 · 1.8K citations

P53 Function, Tumor Heterogeneity, Medicine +10