A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 6.9K citations · Full text

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

Chunying Du, Min Fang, Yucheng Li et al. · Cell · 2000 · 3.5K citations · Full text

Signal Transduction, Mitochondrial Function, Biochemistry +10

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

Anne M. Verhagen, Paul G. Ekert, Miha Pakusch et al. · Cell · 2000 · 2.3K citations · Full text

Protein Function, Autoimmune Disease, Apoptosis +9

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

Atan Gross, Xiao Ming Yin, Kun Wang et al. · Journal of Biological Chemistry · 1999 · 1.1K citations · Full text

Mitochondrial Dysfunction, Apoptosis, Immunology +17

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

Srinivasa M. Srinivasula, R.P. Hegde, Ayman Saleh et al. · Nature · 2001 · 994 citations

Signal Transduction, Autoimmune Disease, Signaling Pathway +11