Concepedia

The Synthesis and Biological Activity of Certain 4′-Thionucleosides

John A. Secrist, William B. Parker, K.P. Tiwari, Lea Messini, Sue C. Shaddix, Lucy Rose, Leonard L. Bennett, John A. Montgomery

Nucleosides and Nucleotides · 1995 · 23 citations · 16 references

DOI

Concepts

Abstract

Abstract Results are presented on the synthesis and biological activity of several types of 4′-thionucleosides as potential anticancer agents. Detailed studies on the mechanism of action of 4′-thiothymidine are also presented.

References

16

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

P A Furman, M. Davis, Dennis C. Liotta et al. · Antimicrobial Agents and Chemotherapy · 1992 · 234 citations · Full text

, , +9

Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides

John A. Secrist, Kamal N. Tiwari, James M. Riordan et al. · Journal of Medicinal Chemistry · 1991 · 177 citations

, , +13

Asymmetric synthesis and biological evaluation of .beta.-L-(2R,5S)- and .alpha.-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents

Lak Shin Jeong, Raymond F. Schinazi, Joseph Warren Beach et al. · Journal of Medicinal Chemistry · 1993 · 130 citations

, , +17

Synthesis of 4-Thio-D- and -L-ribofuranose and the Corresponding Adenine Nucleosides

Elmer J. Reist, Donald E. Gueffroy, Leon Goodman · Journal of the American Chemical Society · 1964 · 106 citations

, , +12

Preparation and antitumor activity of 4'-thio analogs of 2,2'-anhydro-1-.beta.-D-arabinofuranosylcytosine

Noboru Ototani, Roy L. Whistler · Journal of Medicinal Chemistry · 1974 · 86 citations

, , +5