Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

Education, Cell Biology, Molecular Biology +15

p53 is required for radiation-induced apoptosis in mouse thymocytes

Scott W. Lowe, Earlene M. Schmitt, Sallie W. Smith et al. · Nature · 1993 · 2.9K citations

Medicine, Cell Biology, Oncology +14

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

Fred Bunz, Annie Dutriaux, Christoph Lengauer et al. · Science · 1998 · 2.8K citations

Life Sciences, Cell Biology, Molecular Biology +17

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

Martin Scheffner, Jon M. Huibregtse, Richard D. Vierstra et al. · Cell · 1993 · 2.4K citations

Life Sciences, Cancer Biology, Molecular Biology +15

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

Vjekoslav Dulić, William K. Kaufmann, S J Wilson et al. · Cell · 1994 · 1.5K citations

Medicine, Cell Biology, Oncology +17