p21-Mediated Nuclear Retention of Cyclin B1-Cdk1 in Response to Genotoxic Stress

Fabienne Charrier‐Savournin, Marie‐Thérèse Château, Véronique Gire, +3

Molecular Biology of the Cell

ApoptosisCell ProliferationCell CycleS PhaseCyclin B1-cdk1 +17

DNA damage checkpoint kinase Chk2 triggers replicative senescence

Véronique Gire, Pierre Roux, David Wynford‐Thomas, +2

The EMBO Journal

ChromatinGenome InstabilityDna DamageDna ReplicationCell Death +4

Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies

Véronique Gire, David Wynford‐Thomas

Molecular and Cellular Biology

P53 FunctionFunctional P53Human CellCell RegulationCell Division +12

Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.

Jane Bond, Michele F. Haughton, Jeremy P. Blaydes, +3

PubMed

Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon cancer cells

Lauréline Roger, Laurent Jullien, Véronique Gire, +1

Journal of Cell Science

Cancer BiologyTumor BiologyP53 MutantsMutant P53Cancer Cell Biology +17

Control of Replicative Life Span in Human Cells: Barriers to Clonal Expansion Intermediate Between M1 Senescence and M2 Crisis

Jane Bond, Michele F. Haughton, J M Rowson, +4

Molecular and Cellular Biology

PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS

Véronique Gire, Christopher J. Marshall, David Wynford‐Thomas

Oncogene

Signal TransductionSignaling PathwayCell RegulationReceptor Tyrosine KinaseApoptosis +9

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2

Jeremy P. Blaydes, Véronique Gire, Janet Rowson, +1

Oncogene

Tumor BiologyWild-type P53Cell DeathTransformed Epithelial CellsHigh Levels +7

The p53 Isoform Δ133p53β Promotes Cancer Stem Cell Potential

Nikola Arsic, Gilles Gadéa, Ebba L. Lagerqvist, +7

Stem Cell Reports

Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

Jorge Vera, Lydia Lartigue, Suzanne Vigneron, +7

eLife

Cancer BiologyTumor BiologySignaling PathwayCell RegulationPp2a Activity +15