Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Life Sciences, Genetics, Molecular Genetics +12

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Itaru Urakawa, Yuji Yamazaki, Takashi Shimada et al. · Nature · 2006 · 1.8K citations

Life Sciences, Genetics, Molecular Biology +10

The ß-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel

Saskia J.G. Hoefs, Annemiete W. van der Kemp, Catalin N. Topala et al. · Science · 2005 · 621 citations

Life Sciences, Biochemistry, Physiology +17

Klotho, a Gene Related to a Syndrome Resembling Human Premature Aging, Functions in a Negative Regulatory Circuit of Vitamin D Endocrine System

Hiroshi Tsujikawa, Yoko Kurotaki, Toshihiko Fujimori et al. · Molecular Endocrinology · 2003 · 485 citations · Full text

Medicine, Endocrinology, Genetics +17

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

Seung‐Kuy Cha, Bernardo Ortega, Hiroshi Kurosu et al. · Proceedings of the National Academy of Sciences · 2008 · 414 citations · Full text

Life Sciences, Biochemistry, Cell Biology +17