Concepedia

Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors

Natalia Issaeva, Przemyslaw Bozko, Martin Enge, Marina Protopopova, Lisette G. G. C. Verhoef, Maria G. Masucci, Aladdin Pramanik, Galina Selivanova

Nature Medicine · 2004 · 744 citations · 41 references

DOI

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References

41

Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

, , +15

Requirement for p53 and p21 to Sustain G <sub>2</sub> Arrest After DNA Damage

Fred Bunz, Annie Dutriaux, Christoph Lengauer et al. · Science · 1998 · 2.8K citations

, , +17

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Wei Gu, R G Roeder · Cell · 1997 · 2.6K citations · Full text

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Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

Yunje Cho, Svetlana S. Gorina, Philip D. Jeffrey et al. · Science · 1994 · 2.5K citations

, , +16