Structure–activity studies on diphenylpyrazine derivatives: A novel class of prostacyclin receptor agonists

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

G. V. R. Born · Nature · 1962 · 4.3K citations

Medicine, Biochemistry, Hematology +14

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Synthesis, CoMFA Analysis, and Receptor Docking of 3,5-Diacyl-2,4-Dialkylpyridine Derivatives as Selective A₃ Adenosine Receptor Antagonists

An‐Hu Li, Stefano Moro, Nancy E. Forsyth et al. · Journal of Medicinal Chemistry · 1999 · 180 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), an Orally Available and Long-Acting Prostacyclin Receptor Agonist Prodrug

Keiichi Kuwano, Asami Hashino, Tetsuo Asaki et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 161 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11

Prostaglandin analogs. Part 9. Synthesis of a new chemically and metabolically stable prostacyclin analog with high and long-lasting oral activity

Werner Skuballa, E. Schillinger, C.‐ST. STUERZEBECHER et al. · Journal of Medicinal Chemistry · 1986 · 117 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10